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Fourth dose mRNA COVID-19 vaccines?

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  ECDC and EMA issue advice on fourth doses of mRNA COVID-19 vaccines | European Medicines Agency (europa.eu) News  06/04/2022 The European Centre for Disease Prevention and Control (ECDC) and EMA’s COVID-19 task force (ETF) have concluded that it is too early to consider using a fourth dose of mRNA COVID-19 vaccines (Pfizer’s  Comirnaty  and Moderna’s  Spikevax ) in the general population. However, both agencies agreed that a fourth dose (or second booster) can be given to adults 80 years of age and above after reviewing data on the higher risk of severe COVID-19 in this age group and the protection provided by a fourth dose. ECDC and EMA also noted that there is currently no clear evidence in the EU that vaccine protection against severe disease is waning substantially in adults with normal immune systems aged 60 to 79 years and thus no clear evidence to support the immediate use of a fourth dose. Authorities will continue to monitor data to determine if ...
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Szwedzka statystyka

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Folkhälsomyndigheten   dane z dnia 2020-04-27: Statystyka ogólna Sjukdomsfall: - liczba przypadków - 18 926 (kobiet 10358, mężczyzn 8568) Totalt antal laboratoriebekreftade intensivvårdade:  - liczba przypadków potwierdzonych badaniem laboratoryjnym  w OIOM - 1353 (K 351, M 1002) Avlidna: - zmarli - 2274 (K 991, M 1283) Liczba nowych przypadków/dzień   Tidsserie: Sjukdomsfall per dag = seria danych, liczba przypadków na każdy dzień Liczba zachorowań w grupach wiekowych           Liczba zgonów w grupach wiekowych Sjukdomsfall per åldersgrupp = liczba zachorowań w grupach wiekowych Avlidna per åldersgrupp = liczba zgonów w grupach wiekowych Svensk intensivvård   (szwedzki rejestr OIOM) dane z dnia 2020-04-27 Antal vårdtillfällen   = liczba przypadków (pewna liczba pacjentów jest przenoszona między różnymi oddziałami, dlatego występuje różnica liczby przypadkow/pacjentów) Antal p...
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Viral load dynamics, duration of viral shedding, and infectiousness

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Lancet: "SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis" Findings 79 studies (5340 individuals) on SARS-CoV-2, eight studies (1858 individuals) on SARS-CoV, and 11 studies (799 individuals) on MERS-CoV were included. Mean duration of SARS-CoV-2 RNA shedding was 17·0 days (95% CI 15·5–18·6; 43 studies, 3229 individuals) in upper respiratory tract, 14·6 days (9·3–20·0; seven studies, 260 individuals) in lower respiratory tract, 17·2 days (14·4–20·1; 13 studies, 586 individuals) in stool, and 16·6 days (3·6–29·7; two studies, 108 individuals) in serum samples. Maximum shedding duration was 83 days in the upper respiratory tract, 59 days in the lower respiratory tract, 126 days in stools, and 60 days in serum. Pooled mean SARS-CoV-2 shedding duration was positively associated with age (slope 0·304 [95% CI 0·115–0·493]; p=0·0016). No study detected live virus beyond day 9 of illness, des...
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